Across TCGA pan-cancer cohorts, RNU4-28P RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated RNU4-28P data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher RNU4-28P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU4-28P expression acts as an unfavorable survival marker.

KIRP, CHOL, and UCS are the cancer types where RNU4-28P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.146	0.783	<.001	87	view →
CHOL	OS	Tertile	All	0.019	0.800	<.001	72	view →
UCS	DFS	Tertile	All	0.173	0.536	.005	54	view →
SKCM	OS	Tertile	All	0.569	0.886	<.001	45	view →
READ	OS	Tertile	II,III,IV	0.287	0.816	.001	45	view →
LUAD	DFS	Tertile	IV	0.109	0.714	.001	36	view →
LAML	DFS	Quartile	All	0.358	0.635	.009	30	view →
MESO	OS	Tertile	III,IV	0.052	0.562	.028	18	view →
BRCA	DFS	Tertile	All	0.914	0.952	.016	18	view →
THCA	OS	Tertile	II,III,IV	0.240	0.829	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

Exploration

Same gene, other analysis: RNU4-28P tumor-vs-normal RNA expression · all RNU4-28P data types