Across TCGA pan-cancer cohorts, RNU2-6P RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated RNU2-6P data layer.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher RNU2-6P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNU2-6P expression acts as an unfavorable survival marker, although some lineages such as ESCA and COAD show a favorable association.
LUSC, ESCA, and LGG are the cancer types where RNU2-6P RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.