RNU2-69P

Across TCGA pan-cancer cohorts, RNU2-69P RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RNU2-69P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU2-69P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU2-69P is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, THCA, and BRCA are the cancer types where RNU2-69P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU2-69P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.464	.009	6	view →
THCA	Male	IV	−0.919	.002	2	view →
BRCA	All	IV	+0.635	<.001	2	view →
BLCA	All	All	+0.326	.021	2	view →
LUSC	All	All	+0.293	.005	2	view →
LUAD	Female	II,III,IV	+0.370	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RNU2-69P–HNSC

Open the HNSC breakdown →