Across TCGA pan-cancer cohorts, RNU2-25P RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated RNU2-25P data layer.
The strongest signal is observed in colon adenocarcinoma (COAD), where higher RNU2-25P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU2-25P expression acts as an unfavorable survival marker, although some lineages such as UCS and LAML show a favorable association.
COAD, LUSC, and SKCM are the cancer types where RNU2-25P RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.