RNU2-10P

Across TCGA pan-cancer cohorts, RNU2-10P RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated RNU2-10P data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher RNU2-10P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU2-10P expression acts as an unfavorable survival marker, although some lineages such as KIRC and ESCA show a favorable association.

UVM, HNSC, and BLCA are the cancer types where RNU2-10P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.136	0.919	<.001	90	view →
HNSC	OS	Tertile	III,IV	0.216	0.691	<.001	75	view →
BLCA	OS	Tertile	IV	0.082	0.605	<.001	72	view →
MESO	DFS	Tertile	III,IV	0.043	0.415	<.001	36	view →
TGCT	OS	Tertile	All	0.817	0.968	.021	18	view →
GBM	OS	Tertile	All	0.030	0.416	<.001	18	view →
KIRC	DFS	Tertile	All	0.971	0.867	.027	6	view →
ESCA	DFS	Tertile	III,IV	0.496	0.278	.040	6	view →
LGG	DFS	Tertile	All	0.187	0.428	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

RNU2-10P–UVM (OS)

Open the UVM breakdown →