Across TCGA pan-cancer cohorts, RNU12-2P RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RNU12-2P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where RNU12-2P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU12-2P is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.
KICH, KIRC, and LIHC are the cancer types where RNU12-2P tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU12-2P RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.