Across TCGA pan-cancer cohorts, RNU1-42P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU1-42P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNU1-42P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU1-42P is over-expressed in tumor.
KIRC and LUAD are the cancer types where RNU1-42P tumor–normal differential expression is most reproducible.