Across TCGA pan-cancer cohorts, RNU1-28P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU1-28P’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where RNU1-28P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU1-28P is over-expressed in tumor.
STAD and LUAD are the cancer types where RNU1-28P tumor–normal differential expression is most reproducible.