Across TCGA pan-cancer cohorts, RNU1-153P RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RNU1-153P’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU1-153P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU1-153P is over-expressed in tumor, although a few such as UCEC and LUAD show the opposite, repressed pattern.
HNSC, CHOL, and UCEC are the cancer types where RNU1-153P tumor–normal differential expression is most reproducible.