Across TCGA pan-cancer cohorts, RNU1-14P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU1-14P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNU1-14P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU1-14P is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
KIRC, KICH, and KIRP are the cancer types where RNU1-14P tumor–normal differential expression is most reproducible.