Across TCGA pan-cancer cohorts, RNU1-136P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU1-136P’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RNU1-136P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU1-136P is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.
THCA, BRCA, and KIRP are the cancer types where RNU1-136P tumor–normal differential expression is most reproducible.