Across TCGA pan-cancer cohorts, RNU1-133P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU1-133P’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where RNU1-133P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU1-133P is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.
BRCA and PRAD are the cancer types where RNU1-133P tumor–normal differential expression is most reproducible.