Across TCGA pan-cancer cohorts, RNU1-112P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU1-112P’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU1-112P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU1-112P is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
HNSC and THCA are the cancer types where RNU1-112P tumor–normal differential expression is most reproducible.