Across TCGA pan-cancer cohorts, RNU1-1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated RNU1-1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RNU1-1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RNU1-1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, LUSC, and THCA are the cancer types where RNU1-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	1.000	0.836	.018	72	view →
LUSC	DFS	Tertile	III,IV	0.224	0.573	.002	45	view →
THCA	OS	Tertile	IV	0.095	0.966	<.001	36	view →
BLCA	OS	Tertile	IV	0.225	0.620	<.001	33	view →
UVM	OS	Tertile	III,IV	0.241	0.765	.002	33	view →
KICH	DFS	Tertile	All	0.379	0.889	.003	30	view →
SKCM	OS	Tertile	II,III,IV	0.505	0.752	.003	27	view →
LIHC	OS	Tertile	II,III,IV	0.376	0.720	.032	18	view →
KIRC	OS	Tertile	All	0.699	0.819	.015	18	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
LUAD	DFS	Tertile	IV	0.484	0.936	.001	18	view →
CESC	DFS	Tertile	II,III,IV	0.615	0.818	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

Exploration

Same gene, other analysis: RNU1-1 tumor-vs-normal RNA expression · all RNU1-1 data types