RNPEPL1

Across TCGA patient cohorts, RNPEPL1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNPEPL1-associated genes across cancer lineages are A-Raf_pS299, Lck, and ACC_pS79. Each is linked with RNPEPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNPEPL1-to-partner and partner-to-RNPEPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by RNPEPL1-low versus RNPEPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNPEPL1→partner) and Y-score (partner→RNPEPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.168	-3.169	.001	.019	3	2
COAD	Lck →	+0.659	+2.832	<.001	.035	3	2
UCEC	ACC_pS79 →	+0.327	+3.169	.030	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.157	-2.999	.033	.035	3	1
UCEC	Ku80 →	+0.258	+1.598	.012	.044	3	1
UCEC	p62 Lck ligand →	+0.411	+3.169	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

A-Raf_pS299 by RNPEPL1 expression — UCEC

Explore this box plot interactively →