RNPEP

Across TCGA patient cohorts, RNPEP mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible RNPEP-associated genes across cancer lineages are Astrocytes, Macrophages, and Neurons. Each is linked with RNPEP in more than 1 cancer types. Because this analysis shows association rather than direction, both RNPEP-to-partner and partner-to-RNPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Astrocytes grouped by RNPEP-low versus RNPEP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNPEP→partner) and Y-score (partner→RNPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Astrocytes →	+0.065	+2.844	<.001	.007	3	1
COAD	Macrophages →	+0.016	+2.440	.034	.019	3	1
SKCM	Neurons →	+0.026	+2.719	.001	.003	3	1
SKCM	pro B-cells →	+0.111	+2.340	.004	.019	3	1
UCEC	CD8+ naive T-cells →	+0.033	+2.212	.020	.034	3	1
SKCM	Myocytes →	+0.037	+2.732	.025	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Astrocytes by RNPEP expression — COAD

Explore this box plot interactively →