Across TCGA pan-cancer cohorts, RNPC3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RNPC3 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher RNPC3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RNPC3 expression acts as an unfavorable survival marker.

READ, BRCA, and LIHC are the cancer types where RNPC3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.054	0.934	<.001	24	view →
BRCA	OS	Median	III,IV	0.176	0.833	<.001	20	view →
LIHC	DFS	Median	All	0.054	0.553	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNPC3 tumor-vs-normal RNA expression · all RNPC3 data types