RNMT

Across TCGA pan-cancer cohorts, RNMT mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RNMT data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RNMT mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RNMT expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where RNMT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.166	0.973	.010	50	view →
CCRCC	OS	Median	All	0.890	1.000	.003	30	view →
LUAD	OS	Median	III,IV	0.911	0.325	.013	7	view →
PDAC	OS	Median	IV	0.951	0.381	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RNMT–HNSC (OS)

Open the HNSC breakdown →