RNMT

Across TCGA patient cohorts, RNMT mutation is significantly associated with the RNA expression of many other genes, with 3,602 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNMT-associated genes across cancer lineages are LINC01072, MIR588, and MIR4744. Each is linked with RNMT in more than 1 cancer types. Because this analysis shows association rather than direction, both RNMT-to-partner and partner-to-RNMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01072 grouped by RNMT-low versus RNMT-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNMT→partner) and Y-score (partner→RNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LINC01072 →	+0.118	+5.241	<.001	.007	3	2
SKCM	MIR588 →	+0.319	+4.743	<.001	.005	3	2
UCEC	MIR4744 →	+0.266	+1.785	.005	.003	3	2
LUAD	RCC2P5 →	+0.030	+4.798	<.001	.006	3	2
UCEC	RNU6-353P →	+0.509	+1.877	<.001	<.001	3	2
UCEC	RNA5SP420 →	+0.408	+1.645	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,602 associations by consensus.

LINC01072 by RNMT expression — HNSC

Explore this box plot interactively →