Across TCGA patient cohorts, RNLS mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNLS-associated genes across cancer lineages are CD49b, EGFR_pY1068, and eIF4E. Each is linked with RNLS in more than 1 cancer types. Because this analysis shows association rather than direction, both RNLS-to-partner and partner-to-RNLS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNLS→partner) and Y-score (partner→RNLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD49b →	-0.228	-2.986	.046	.035	3	2
UCEC	EGFR_pY1068 →	-0.267	-2.700	.008	.006	3	1
UCEC	eIF4E →	+0.175	+3.335	.039	.005	3	1
UCEC	eIF4G →	+0.338	+2.000	.006	.030	3	1
UCEC	A-Raf_pS299 →	-0.159	-3.321	<.001	.009	3	1
UCEC	ERK2 →	+0.266	+2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

RNLS survival (RNA) · tumor vs normal (RNA) · all RNLS data types