RNGTT

Across TCGA patient cohorts, RNGTT mutation is significantly associated with the RNA expression of many other genes, with 3,448 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNGTT-associated genes across cancer lineages are NDUFA4P2, MIR6856, and OR13H1. Each is linked with RNGTT in more than 2 cancer types. Because this analysis shows association rather than direction, both RNGTT-to-partner and partner-to-RNGTT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA4P2 grouped by RNGTT-low versus RNGTT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNGTT→partner) and Y-score (partner→RNGTT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NDUFA4P2 →	+0.192	+3.300	<.001	.007	3	3
LUSC	MIR6856 →	+0.486	+3.245	.007	.009	3	2
COAD	OR13H1 →	+0.127	+4.173	<.001	.003	3	2
LUAD	HPRT1P3 →	+0.072	+5.444	<.001	.002	3	2
LUAD	MIR548AW →	+0.362	+6.108	<.001	.001	3	2
UCEC	ONECUT3 →	+0.483	+2.595	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,448 associations by consensus.

NDUFA4P2 by RNGTT expression — SKCM

Explore this box plot interactively →