RNGTT

Across TCGA patient cohorts, RNGTT mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNGTT-associated genes across cancer lineages are GAPDH, MEK1, and Caspase-7-cleavedD198. Each is linked with RNGTT in more than 1 cancer types. Because this analysis shows association rather than direction, both RNGTT-to-partner and partner-to-RNGTT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by RNGTT-low versus RNGTT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNGTT→partner) and Y-score (partner→RNGTT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.382	+2.115	.023	.016	3	2
UCEC	MEK1 →	+0.466	+2.115	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.578	+2.090	.001	<.001	3	2
UCEC	14-3-3_beta →	-0.085	-2.295	.007	.005	3	1
UCEC	eEF2 →	+0.352	+2.906	.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.305	-1.836	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

GAPDH by RNGTT expression — UCEC

Explore this box plot interactively →