RNF8

Across TCGA pan-cancer cohorts, RNF8 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RNF8 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RNF8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RNF8 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where RNF8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	1.000	0.567	.012	20	view →
UCEC	OS	Median	III,IV	1.000	0.353	.021	8	view →
PDAC	OS	Tertile	II,III,IV	0.733	0.238	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RNF8–LSCC (DFS)

Open the LSCC breakdown →