RNF8

Across TCGA patient cohorts, RNF8 protein abundance is significantly associated with the RNA expression of many other genes, with 638 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RNF8-associated genes across cancer lineages are DNAJC17, PODXL2, and INSL6. Each is linked with RNF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF8-to-partner and partner-to-RNF8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF8 versus DNAJC17 in PDAC, with a Pearson correlation of 0.86.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF8→partner) and Y-score (partner→RNF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	DNAJC17 →	+0.437	+0.442	.001	.008	3	1
PDAC	PODXL2 →	-1.038	-0.363	<.001	.002	3	1
PDAC	INSL6 →	-0.539	-0.363	.001	.002	3	1
PDAC	EMC4 →	+0.438	+0.363	<.001	.002	3	1
PDAC	CEP85 →	-0.641	-0.363	<.001	.002	3	1
PDAC	UBE2M →	+0.346	+0.363	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 638 associations by consensus.

RNF8 vs DNAJC17 — PDAC

Explore this scatter interactively →