RNF8

Across TCGA patient cohorts, RNF8 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF8-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and Di-Ras3. Each is linked with RNF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF8-to-partner and partner-to-RNF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RNF8-low versus RNF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF8→partner) and Y-score (partner→RNF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.470	+2.415	.001	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.752	+3.827	.001	<.001	3	2
UCEC	Di-Ras3 →	-0.159	-3.156	.007	.018	3	2
UCEC	EGFR_pY1068 →	-0.201	-2.459	.046	.019	3	1
UCEC	eIF4E →	+0.232	+2.415	.006	.003	3	1
UCEC	Fibronectin →	-0.280	-1.990	.034	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MEK1 by RNF8 expression — UCEC

Explore this box plot interactively →