RNF8

Across TCGA cell cohorts, RNF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,484 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF8-associated GO terms across cancer lineages are Negative regulation of RNA export from nucleus, Sperm DNA condensation, and DNA-templated transcription initiation. Each is linked with RNF8 in more than 16 cancer types. Because this analysis shows association rather than direction, both RNF8-to-partner and partner-to-RNF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA export from nucleus grouped by RNF8-low versus RNF8-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF8→partner) and Y-score (partner→RNF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of RNA export from nucleus →	+0.179	+0.710	<.001	<.001	3	17
URINARY_TRACT	Sperm DNA condensation →	+0.204	+1.108	<.001	<.001	3	17
BREAST	DNA-templated transcription initiation →	+0.066	+0.914	<.001	<.001	3	16
BONE	DNA integrity checkpoint signaling →	+0.090	+0.440	.003	<.001	3	15
OESOPHAGUS	DNA replication initiation →	+0.177	+0.836	.001	.002	3	15
STOMACH	Cell cycle checkpoint signaling →	+0.071	+0.558	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,484 associations by consensus.

Negative regulation of RNA export from nucleus by RNF8 expression — STOMACH

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