RNF8

Across TCGA cell cohorts, RNF8 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF8-associated genes across cancer lineages are DRD3, OR2M5, and OR10W1. Each is linked with RNF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF8-to-partner and partner-to-RNF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DRD3 grouped by RNF8-low versus RNF8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF8→partner) and Y-score (partner→RNF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DRD3 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR2M5 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DRD3 by RNF8 expression — LARGE_INTESTINE

Explore this box plot interactively →