RNF7

Across TCGA pan-cancer cohorts, RNF7 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RNF7 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RNF7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF7 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where RNF7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.404	0.894	.002	39	view →
CCRCC	DFS	Tertile	All	0.571	0.904	<.001	39	view →
PDAC	OS	Quartile	All	0.797	0.500	.004	5	view →
HNSC	OS	Tertile	II,III,IV	0.828	0.599	.027	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RNF7–LSCC (DFS)

Open the LSCC breakdown →