Across TCGA pan-cancer cohorts, RNF6P1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNF6P1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RNF6P1 RNA is repressed in tumor relative to normal tissue. In most cancer types RNF6P1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, CHOL, and KICH are the cancer types where RNF6P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF6P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.030	.018	5	view →
CHOL	Male	All	+0.061	.049	1	view →
KICH	Female	All	−0.016	.028	1	view →
HNSC	All	All	+0.012	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: RNF6P1 RNA expression & survival · all RNF6P1 data types