Across TCGA pan-cancer cohorts, RNF5 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RNF5 data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher RNF5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RNF5 expression acts as an unfavorable survival marker.

STAD, BLCA, and COAD are the cancer types where RNF5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.222	0.729	.004	12	view →
BLCA	DFS	Median	All	0.241	0.628	.005	12	view →
COAD	DFS	Median	All	0.223	0.690	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNF5 tumor-vs-normal RNA expression · all RNF5 data types