Across TCGA pan-cancer cohorts, RNF5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNF5 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RNF5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RNF5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where RNF5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.906	0.492	.003	25	view →
PDAC	DFS	Tertile	All	0.273	0.644	.008	15	view →
UCEC	OS	Quartile	III,IV	1.000	0.334	.042	4	view →
HNSC	OS	Quartile	All	0.259	1.000	.021	4	view →
LUAD	DFS	Quartile	II,III,IV	0.112	0.705	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RNF5 tumor-vs-normal RNA expression · all RNF5 data types