RNF44

Across TCGA patient cohorts, RNF44 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF44-associated genes across cancer lineages are ATM, A-Raf_pS299, and Cyclin-B1. Each is linked with RNF44 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF44-to-partner and partner-to-RNF44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RNF44-low versus RNF44-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF44→partner) and Y-score (partner→RNF44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.446	-3.446	.008	.005	3	3
UCEC	A-Raf_pS299 →	-0.131	-2.000	.003	.030	3	2
UCEC	Cyclin-B1 →	+0.606	+2.584	.004	.010	3	2
UCEC	EGFR_pY1068 →	-0.275	-1.765	.003	.014	3	1
UCEC	eIF4E →	+0.162	+3.183	.040	.009	3	1
UCEC	ERK2 →	+0.198	+1.765	.006	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by RNF44 expression — UCEC

Explore this box plot interactively →