RNF44

Across TCGA cell cohorts, RNF44 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF44-associated genes across cancer lineages are TAFA1, TMC3, and DAZ4. Each is linked with RNF44 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF44-to-partner and partner-to-RNF44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAFA1 grouped by RNF44-low versus RNF44-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF44→partner) and Y-score (partner→RNF44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
LARGE_INTESTINE	TMC3 →	+0.057	+3.648	<.001	.002	3	1
LARGE_INTESTINE	DAZ4 →	+0.123	+3.240	.004	.004	3	1
LARGE_INTESTINE	DAZ2 →	+0.127	+3.678	.004	.001	3	1
LARGE_INTESTINE	SFTPB →	+0.198	+3.548	<.001	.004	2	1
LARGE_INTESTINE	PNMA3 →	+0.156	+2.781	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TAFA1 by RNF44 expression — LARGE_INTESTINE

Explore this box plot interactively →