RNF43

Across TCGA pan-cancer cohorts, RNF43 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated RNF43 data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher RNF43 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RNF43 expression acts as an unfavorable survival marker, although some lineages such as PAAD and UCEC show a favorable association.

BRCA, COAD, and SARC are the cancer types where RNF43 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.107	0.578	.007	12	view →
COAD	OS	Median	IV	0.045	0.659	<.001	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
STAD	OS	Median	All	0.325	0.672	.013	6	view →
ESCA	DFS	Median	All	0.320	0.537	.029	6	view →
PAAD	DFS	Median	II,III,IV	0.595	0.281	.028	4	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
SKCM	OS	Median	III,IV	0.216	0.721	.001	3	view →
UCEC	DFS	Median	All	0.893	0.618	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

RNF43–BRCA (OS)

Open the BRCA breakdown →