RNF43

Across TCGA patient cohorts, RNF43 protein abundance is significantly associated with the protein abundance of many other proteins, with 2,772 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RNF43-associated proteins across cancer lineages are SHANK1_S890, SHANK2_S581, and SHANK3_S1606. Each is linked with RNF43 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF43-to-partner and partner-to-RNF43 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF43 versus SHANK1_S890 in GBM, with a Pearson correlation of 0.50.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF43→partner) and Y-score (partner→RNF43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SHANK1_S890 →	+1.632	+1.111	<.001	<.001	3	1
GBM	SHANK2_S581 →	+1.334	+1.068	<.001	<.001	3	1
GBM	SHANK3_S1606 →	+0.398	+0.992	.001	<.001	3	1
GBM	SHANK3_S679 →	+0.538	+0.796	<.001	<.001	3	1
GBM	SHANK3_S688 →	+0.704	+0.726	<.001	<.001	3	1
GBM	SHANK3_S775 →	+0.885	+1.293	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,772 associations by consensus.

RNF43 vs SHANK1_S890 — GBM

Explore this scatter interactively →