RNF43

Across TCGA patient cohorts, RNF43 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF43-associated genes across cancer lineages are ATM, EGFR_pY1173, and ACC_pS79. Each is linked with RNF43 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF43-to-partner and partner-to-RNF43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RNF43-low versus RNF43-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF43→partner) and Y-score (partner→RNF43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.513	-2.321	<.001	.032	3	3
COAD	EGFR_pY1173 →	+0.098	+2.321	.007	.033	3	2
COAD	ACC_pS79 →	-0.258	-1.691	.024	.043	3	2
COAD	LKB1 →	+0.090	+1.708	.016	.026	3	2
UCEC	MEK1 →	+0.270	+1.459	.013	.011	3	2
COAD	Mre11 →	+0.110	+1.708	.014	.026	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ATM by RNF43 expression — COAD

Explore this box plot interactively →