RNF43

Across TCGA cell cohorts, RNF43 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,517 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible RNF43-associated GO terms across cancer lineages are Actin filament-based transport, Negative regulation of myeloid leukocyte mediated immunity, and Negative regulation of mast cell degranulation. Each is linked with RNF43 in more than 8 cancer types. Because this analysis shows association rather than direction, both RNF43-to-partner and partner-to-RNF43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament-based transport grouped by RNF43-low versus RNF43-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF43→partner) and Y-score (partner→RNF43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Actin filament-based transport →	+0.190	+3.837	<.001	<.001	3	9
OESOPHAGUS	Negative regulation of myeloid leukocyte mediated immunity →	+1.741	+2.103	.005	.001	3	8
OESOPHAGUS	Negative regulation of mast cell degranulation →	+1.476	+2.103	.005	.001	3	8
OVARY	AV node cell to bundle of His cell communication by electrical coupling →	-0.938	-1.022	<.001	.001	3	8
STOMACH	Body fluid secretion →	+0.147	+3.043	<.001	<.001	3	8
URINARY_TRACT	Negative regulation of delayed rectifier potassium channel activity →	+1.434	+0.972	<.001	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,517 associations by consensus.

Actin filament-based transport by RNF43 expression — STOMACH

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