RNF4

Across TCGA pan-cancer cohorts, RNF4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RNF4 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RNF4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF4 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where RNF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	III,IV	0.215	0.958	.008	26	view →
CCRCC	OS	Tertile	All	0.775	1.000	.003	15	view →
PDAC	DFS	Median	III,IV	0.125	0.962	.019	8	view →
HNSC	DFS	Median	III,IV	0.899	1.000	.028	3	view →
GBM	DFS	Tertile	All	0.573	0.322	.032	3	view →
LUAD	DFS	Median	II,III,IV	0.234	0.770	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RNF4–LSCC (DFS)

Open the LSCC breakdown →