Across TCGA pan-cancer cohorts, RNF39 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated RNF39 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RNF39 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF39 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC and HNSC are the cancer types where RNF39 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.363	0.947	.002	25	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.895	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: RNF39 tumor-vs-normal RNA expression · all RNF39 data types