RNF38

Across TCGA patient cohorts, RNF38 mutation is significantly associated with the RNA expression of many other genes, with 4,149 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF38-associated genes across cancer lineages are RNA5SP198, RNU6-338P, and HMGN1P32. Each is linked with RNF38 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF38-to-partner and partner-to-RNF38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP198 grouped by RNF38-low versus RNF38-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF38→partner) and Y-score (partner→RNF38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP198 →	+0.305	+5.144	<.001	.003	3	2
LUSC	RNU6-338P →	+0.569	+6.191	<.001	.001	3	2
LUSC	HMGN1P32 →	+0.264	+5.151	<.001	.007	3	2
LUSC	PHBP15 →	+0.081	+5.548	<.001	.004	3	2
UCEC	RNVU1-28 →	+0.551	+1.454	<.001	.004	3	2
CESC	RN7SL415P →	+0.151	+4.812	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,149 associations by consensus.

RNA5SP198 by RNF38 expression — CESC

Explore this box plot interactively →