RNF38

Across TCGA patient cohorts, RNF38 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF38-associated genes across cancer lineages are p27_pT198, Annexin-1, and eIF4G. Each is linked with RNF38 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF38-to-partner and partner-to-RNF38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by RNF38-low versus RNF38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF38→partner) and Y-score (partner→RNF38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.092	+2.700	.008	.005	3	2
UCEC	Annexin-1 →	+0.451	+1.720	.008	.025	3	2
UCEC	eIF4G →	+0.252	+1.906	.012	.015	3	1
UCEC	JNK2 →	+0.157	+2.486	.014	.009	3	1
UCEC	MEK1 →	+0.347	+2.321	.003	<.001	3	1
UCEC	MSH2 →	-0.148	-1.674	.048	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

p27_pT198 by RNF38 expression — UCEC

Explore this box plot interactively →