RNF38

Across TCGA cell cohorts, RNF38 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF38-associated genes across cancer lineages are USP29, LBHD2, and GHRHR. Each is linked with RNF38 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF38-to-partner and partner-to-RNF38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP29 grouped by RNF38-low versus RNF38-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF38→partner) and Y-score (partner→RNF38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	USP29 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	LBHD2 →	+0.130	+4.273	<.001	.006	3	1
BLOOD_Leukemia	GHRHR →	+0.211	+4.705	.008	.003	3	1
BLOOD_Leukemia	GFRAL →	+0.025	+5.569	<.001	.001	3	1
BLOOD_Leukemia	LRRTM3 →	+0.004	+4.539	<.001	.007	3	1
BLOOD_Leukemia	KRTAP3-1 →	+0.028	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

USP29 by RNF38 expression — LARGE_INTESTINE

Explore this box plot interactively →