RNF38

Across TCGA cell cohorts, RNF38 mutation is significantly associated with the mutation status of many other genes, with 647 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF38-associated genes across cancer lineages are AGO1, INO80D, and SP1. Each is linked with RNF38 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF38-to-partner and partner-to-RNF38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGO1 grouped by RNF38-low versus RNF38-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF38→partner) and Y-score (partner→RNF38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AGO1 →	+4.087	+5.044	.001	.001	1	3
BLOOD_Leukemia	INO80D →	+2.975	+3.794	.006	.006	1	3
LARGE_INTESTINE	SP1 →	+2.865	+4.217	.007	.007	1	3
BLOOD_Leukemia	TAPBPL →	+4.560	+4.870	<.001	<.001	1	2
BLOOD_Leukemia	USP3 →	+4.560	+4.309	.007	.007	1	2
BLOOD_Leukemia	DHRS1 →	+4.560	+4.309	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 647 associations by consensus.

AGO1 by RNF38 expression — LARGE_INTESTINE

Explore this box plot interactively →