RNF34

Across TCGA pan-cancer cohorts, RNF34 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNF34’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where RNF34 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RNF34 is over-expressed in tumor.

CCRCC and LUAD are the cancer types where RNF34 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF34 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	+0.301	.005	1	view →
LUAD	Female	II,III,IV	+0.234	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

RNF34–CCRCC

Open the CCRCC breakdown →