RNF32

Across TCGA patient cohorts, RNF32 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF32-associated genes across cancer lineages are p90 RSK, PCNA, and ATM. Each is linked with RNF32 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF32-to-partner and partner-to-RNF32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by RNF32-low versus RNF32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF32→partner) and Y-score (partner→RNF32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.138	+1.179	.020	.041	3	2
UCEC	PCNA →	+0.164	+1.700	.014	.040	3	2
UCEC	ATM →	-0.515	-2.156	<.001	.002	3	2
UCEC	14-3-3_beta →	-0.079	-1.973	.011	.008	3	1
UCEC	eIF4E →	+0.134	+2.472	.040	.010	3	1
UCEC	eIF4G →	+0.218	+1.700	.023	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

p90 RSK by RNF32 expression — UCEC

Explore this box plot interactively →