RNF2P1

Across TCGA pan-cancer cohorts, RNF2P1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RNF2P1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RNF2P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF2P1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRP, KICH, and HNSC are the cancer types where RNF2P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF2P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	+0.558	.002	8	view →
KICH	Female	II,III,IV	−0.718	<.001	7	view →
HNSC	All	All	+0.103	.002	7	view →
THCA	Male	All	−0.509	<.001	6	view →
LIHC	Female	All	+0.405	<.001	6	view →
COAD	All	II,III,IV	+0.187	.001	6	view →
KIRC	All	All	−0.109	.002	5	view →
BRCA	Female	II,III,IV	+0.189	.006	4	view →
LUSC	All	All	+0.117	.007	4	view →
PRAD	All	All	+0.314	<.001	2	view →
UCEC	All	All	+0.210	.042	2	view →
CHOL	All	All	+1.281	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RNF2P1–KIRP

Open the KIRP breakdown →