RNF26

Across TCGA pan-cancer cohorts, RNF26 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RNF26 data layer compared with 30 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RNF26 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF26 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

UCEC, GBM, and CCRCC are the cancer types where RNF26 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.492	1.000	.018	18	view →
GBM	OS	Tertile	All	0.830	0.453	.008	10	view →
CCRCC	OS	Median	II,III,IV	0.887	0.430	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RNF26–UCEC (DFS)

Open the UCEC breakdown →