RNF223

Across TCGA patient cohorts, RNF223 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,527 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible RNF223-associated proteins across cancer lineages are EPS8L2, PKP3, and CTNND1. Each is linked with RNF223 in more than 4 cancer types. Because this analysis shows association rather than direction, both RNF223-to-partner and partner-to-RNF223 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF223 versus EPS8L2 in HNSC, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF223→partner) and Y-score (partner→RNF223) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EPS8L2 →	+0.550	+0.940	<.001	<.001	3	5
HNSC	PKP3 →	+0.897	+0.919	<.001	<.001	3	5
HNSC	CTNND1 →	+0.250	+0.710	<.001	<.001	3	4
HNSC	S100P →	+1.105	+0.945	<.001	.001	3	4
UCEC	JPT2 →	+0.309	+0.887	.001	<.001	3	4
UCEC	KIFC3 →	+0.749	+0.761	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,527 associations by consensus.

RNF223 vs EPS8L2 — HNSC

Explore this scatter interactively →