RNF223

Across TCGA patient cohorts, RNF223 protein abundance is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible RNF223-associated genes across cancer lineages are HSPD1P18, EXOSC3, and PODXL2. Each is linked with RNF223 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF223-to-partner and partner-to-RNF223 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF223 versus HSPD1P18 in UCEC, with a Pearson correlation of 0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF223→partner) and Y-score (partner→RNF223) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPD1P18 →	+1.722	+1.666	.003	<.001	3	1
HNSC	EXOSC3 →	-0.697	-1.561	<.001	<.001	3	1
HNSC	PODXL2 →	+1.536	+1.518	.003	<.001	3	1
HNSC	CAAP1 →	-1.306	-1.675	.006	.007	3	1
HNSC	UBE2L2 →	-1.138	-1.612	.002	<.001	3	1
HNSC	ZNF414 →	-0.973	-1.841	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

RNF223 vs HSPD1P18 — UCEC

Explore this scatter interactively →