RNF223

Across TCGA cell cohorts, RNF223 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,060 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RNF223-associated GO terms across cancer lineages are Response to indole-3-methanol, Cellular response to indole-3-methanol, and Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Each is linked with RNF223 in more than 12 cancer types. Because this analysis shows association rather than direction, both RNF223-to-partner and partner-to-RNF223 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to indole-3-methanol grouped by RNF223-low versus RNF223-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF223→partner) and Y-score (partner→RNF223) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Response to indole-3-methanol →	+0.302	+1.999	<.001	<.001	3	13
URINARY_TRACT	Cellular response to indole-3-methanol →	+0.248	+2.366	<.001	<.001	3	12
URINARY_TRACT	Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.142	+1.659	<.001	.007	3	11
STOMACH	Protein localization to cell junction →	+0.115	+1.267	<.001	<.001	3	11
URINARY_TRACT	Positive regulation of iron ion transport →	+1.732	+1.493	<.001	.007	3	11
URINARY_TRACT	Positive regulation of iron ion transmembrane transport →	+1.732	+1.493	<.001	.007	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,060 associations by consensus.

Response to indole-3-methanol by RNF223 expression — STOMACH

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